Saulat U Khan, Tahira M Cheema, Aftab H Bhatti, Azmat Rashid, Amir Bashir, G Murtaza Cheema, A Majeed, Khalid Waheed.
Results of short term Chemotherapy: A study in 90 cases.
Biomedica Jan ;13(1):21-5.
Newly diagnosed 90 patients of pulmonary tuberculosis with no history of previous antituberculous therapy, who were sputum AFB positive were selected and randomized. These patients were divided into 3 groups according to the treatment regimen. To the group `A` Streptomycin, Isoniazid and Ethambutol, to group `B` Rifampicin, Isoniazid and pyrazinamide and to group `C` Rifampicin, Isoniazid, Ethambutol were given for the treatment. To assess the tolerability, the SGOT, SGPT, serum uric acid and serum bilirubin were determined before and after completion of treatment. Efficacy of these drugs was determined by the bacteriological status i.e., sputum conversion by AFB smear and culture. There was significant increase of SGOT, SGPT in group `B` and `C` in the first month of treatment. Uric Acid level in the group `B` increased significantly throughout the treatment.
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