Avinash De Sousa.
Metabolic syndrome and antipsychotic drugs (a review).
J Pak Psych Soc Jan ;9(2):53-61.

Metabolic syndrome is characterised by a constellation of obesity, dyslipidemia, insulin insensitivity, deranged glucose metabolism and hypertension. The interface between psychiatry and metabolic syndrome is of importance today due to the increasing recognition of this syndrome among patients receiving psychotropic medications. Antipsychotics and possibly other psychotropic drugs like antidepressants can induce weight gain or worsen other metabolic parameters, particularly increasing the cardiovascular risk factors. Mounting evidence has suggested decreased life expectancy in psychiatric patients by one to three decades. Changes associated with metabolic syndrome appear to play a significant role in them. This article reviews metabolic syndrome in association with psychiatric illnesses, antipsychotic treatment and recent guidelines for its detection and management.

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