Yang Kok Lee, Lam Kit Lay, Mansor Sharif Mahsufi, Teoh Siang Guan, Sunderasan Elumalai, Ong Ming Thong.
Anti-proliferation effect of hevea brasiliensis latex B-serum on human breast epithelial cells.
Pak J Pharm Sci Jan ;25(3):645-50.

The rubber tree (Hevea brasiliensis) extracts are becoming increasingly visible in pharmaceutical and therapeutical research. The present study is aimed at examining the specific anti-proliferation property of H. brasiliensis latex B-serum sub-fractions against human breast cancer epithelial cell lines MCF-7 and MDA-MB231. The results showed that the latex whole B-serum and DBP sub-fraction exerted a specific anti-proliferation activity against cancer-origin cells MDA-MB231 but had little effect on non-cancer-origin cells. On the other hand, the anti-proliferative activity was diminished in the pre-heated B-serum fractions. With the low toxicity that the B-serum demonstrated previously in Brine Shrimp Lethality Test (BSLT), the present results suggest the potential use of the B-serum sub-fractions in cancer treatment.

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