Talat Syeda, Abdul Sattar Muhammad Hashim, Husan Afroz Rizvi, Syed Murtaza Hadi.
Serum S100B in patients with brain tumours undergoing craniotomy.
J Coll Physicians Surg Pak Jan ;23(2):112-5.

Objective: To determine pre- and postoperative serum S100B concentrations in patients with intracranial tumours that underwent craniotomy and compare the values with healthy controls. Study Design: An observational, comparative study. Place and Duration of Study: Neurosurgical Ward, Jinnah Postgraduate Medical Centre. Karachi, from May 2007 to April 2008. Methodology: Serum S100B was measured pre- and postoperatively on days 1, 2 and 7 in 18 healthy controls and similar number of patients who underwent craniotomy for intracranial tumours. Mean pre-operative patients and control values were compared using Mann-Whitney (unpaired) or Wilcoxon (paired) tests for comparing between pre- and postoperative values. The p-value was considered significant at < 0.05. Results: Serum S100B concentrations were significantly higher in patients with mean value of 0.19 ± 0.12 µg/L than in healthy controls (mean 0.03 ± 0.01, p < 0.0005). Significantly raised serum S100B concentrations were observed in all postoperative samples when compared with pre-operative samples. S100B concentrations significantly increased on postoperative day 1 (mean = 0.90 ± 1.07 µg/L, p < 0.0005), decreased on day 2 (mean = 0.84 ± 0.57 µg/L, p < 0.0005). The concentrations further declined on day 7 (mean = 0.44 ± 0.43 µg/L, p = 0.005). Conclusion: The significantly high postoperative concentrations of S100B in patients appear as a consequence of tissue damage due to surgical procedures. The absence of fall of the S100B concentration in serum from the peak value on postoperative day 1 and day 2 could provide early warning of brain tissue damage leading to neurological deterioration.

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