Pushpa Goswami, Hem Lata, Samreen Memon, Lal Baksh Khaskhelli.
Excessive placental calcification observed in PIH patients and its relation to fetal outcome.
J Liaquat Uni Med Health Sci Jun ;11(3):143-8.

OBJECTIVE: To see the morphological changes in excessive placental calcification in pregnancy induced hypertension (PIH) and its relation with fetal outcome. STUDY DESIGN: Prospective comparative study. PLACE AND DURATION: This study was conducted from June 2008 to July 2009 at the department of Anatomy of Liaquat University of Medical & Health Sciences Jamshoro and placentae were collected from department of Gynecology & Obstetrics of Liaquat University Hospital. MATERIAL AND METHODS: Eighty freshly delivered placentae were collected from labor room and gynecology operation theatre of Liaquat University Hospital. Forty placentae from parturient that had pregnancy induced hypertension (PIH) & forty placentae from parturient belonged to uncomplicated pregnancy (control group). Ages of all parturient were between 17 to 32 years. Fetal outcome and data was recorded. Placentae were measured on a weighing machine graduated in grams and diameter was measured with the help of a measuring tape in centimeters. Approximately five mm piece of placenta was taken and processed for histological examination. RESULTS: The weight of placenta in control group ranges from 450 to 650 gm with a mean weight of 526.25±8.414 gm having diameter from 19 to 24 cm with a mean of 21.225±0.2148cm. In PIH group weight of placenta ranges from 200 to 550gm with a mean weight of 432.25 ± 11.889gm with diameter ranges from 10 to 16cms with a mean14.208 ± 0.1914cm. The difference in weight and diameter of placenta in PIH was found statistically significant when compared with weight and diameter of normal placentae. The birth weight of new born babies in control group was 1.8 kg to 3.6 kg with mean of 2.790± 0.0689kg. In PIH group the fetal weight was 1.4 kg to 3.0 kg with mean weight of 2.195 ±0.0703kg. CONCLUSION: Fetal outcome in terms of birth weight of newborn to mother having PIH and calcification of placentae (grossly and microscopically) was poor as compared to control group.

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