Evangelos A Dimitriadis, Nikolaos Ch Syrmos, Anastasios Orologas.
Efficacy of interferon in multiple sclerosis.
Pak J Neurological Sci Jan ;8(2):15-8.

Introduction of interferon b-1b in the therapeutic strategy against Multiple Sclerosis has resulted in a great amelioration of treatment in various terms. Relapse rates, delaying progression of the activity, improvement of imaging outcomes as well as reduction of disease activity itself consist great achievements against a pathological condition that challenged medical effectiveness throughout decades. Two recombinant human IFN-1a and an IFN-1b preparations have been proved effected and well tolerated. We reviewed the most important literature concerning pharmacodynamics, medical efficacy, tolerability and adverse effects of interferon-b usage. In parallel, despite the wide range of trials referring to INF-b treatment, we tried to categorize results of main trials in order to present our conclusions systematically.

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