Abdul Khaliq Abro, Javed Khalil, Ikramud Din Ujjan, Mulazim Hussain Bukhari.
Effect of saturated fat diet and olive oil in thoracic aorta of albino rats.
Pak J Med Health Sci Jan ;5(4):784-90.

Aim: To see the effect of use of oils and fats in the control and experimental groups regarding morphological changes in the thoracic aorta of experimental animals. Materials and methods: 60 albino rats of 32 week old were included in this study, with equal ratio of males and females at optimum atmospheric and hygienic conditions with sufficient quantity of food and water available twenty four hours. A ventral midline abdominothoracic incision was made after replacing albino rats in the ether till death. Aorta was then dissected out and biopsy specimens were kept in labeled jar for fixation, containing formalin and formal calcium. Results: A total 60, 32 weeks albino rats were studied for morphological changes in thoracic aorta. The changes of control and experimental groups were examined. Conclusion: we concluded that the experimental animals which were fed olive oil had less atheromatous lesions, and the group fed with saturated fat diet especially butter showed atheroma formation. Thus olive oil at least can be recommended for the high risk patients of IHD.

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