Hasan Raza, Anis Fatima, Anser Asrar, Shah Murad, Ijaz Fatima.
Use of psyllium husk with new pharmacokinetic and pharmacodynamic considerations.
Pak J Med Health Sci Jan ;5(4):696-8.
Objective: To see effects of Psyllium husk on specific lipid parameters like total cholesterol, LDL-cholesterol and triglycerides, which are important risk factors for development of CHD. Design: It was single blind placebo-controlled study conducted at Department of Pharmacology, BMSI, JPMC-Karachi from March 2011 to June 2011. Results: Consumption of 10 grams Psyllium husk/day lowered serum total cholesterol from 220.83±1.3 to 201.14±2.1, LDL-cholesterol from 180.77±1.1 to 130.11±1.0 and triglycerides from 233.22±5.8 to 188.13±3.1 mg/dl in three months. Changes in all these parameters are highly significant when analyzed biostatistically. Effects by placebo in all lipid parameters were non-significant (P>0.05). Conclusions: Psyllium significantly lowered triglycerides, serum total and LDL-cholesterol concentrations in subjects consuming a low-fat diet. Psyllium is well tolerated and safe when used adjunctive to a low-fat diet in individuals with mild-to-moderate hypercholesterolemia.
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