Shaymyal Moundekhel, Gul Samber Khan, Uzma Afridi.
Management of nephrotic syndrome: Iskdc versus Apn.
Pak J Med Health Sci Jan ;6(1):212-5.

Objective: To compare the frequency of relapses between ISKDC and APN protocol in the treatment of Nephrotic syndrome. Study design: Randomised Control Trial. Setting: Department of Paediatrics, Sandeman Provincial Hospital Quetta, and Balochistan. Duration: One year. Methodology: Total 92 patients, 46 patients in each group, were selected according to non probability purposive sampling including all nephrotic patients age 1 to 16 years keeping in mind the confounders, then allocating them into group 1 receiving ISKDC and group 2 (APN) randomly and following them for a year. First relapse was the end point of study. Results In group 1, 4% of patients relapsed by first month, 13% by three months, 35% by six months, and 72 % by one year. In group 2 no patient relapsed by first month, 2% by 3 months, 15% by six months, and 30% by one year. The P value was 0.026. The longer duration of steroids was significant in reducing the risk of relapse at the end of study (relative risk 0.72) (95% CI 0.60-0.90). Conclusion: APN is superior to ISKDC in preventing relapses in nephrotic syndrome.

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