Humaira Javaid, Aizza Zafar, Jawwad Masood Ahmed, Hasan Ejaz, Muhammad Zubair.
Changing patterns of antimicrobial susceptibility of salmonella typhi at the Children's Hospital Lahore.
Pak J Med Health Sci Jan ;6(1):201-4.

Objective: To evaluate the changing pattern of antimicrobial susceptibility of Salmonella typhi. Study design: Observational study Place and duration of study: The Children’s Hospital Lahore, from January to December 2010. Materials and methods: Blood cultures of 780 clinically suspected patients were performed using brain heart infusion broth. The antimicrobial susceptibility of S. typhi was performed using Kirby Bauer disc diffusion method. Results: A total of 69 isolates of Salmonella species were recovered during above stated period. Frequency of Salmonella typhi was found to be 60(87%), Salmonella paratyphi A 8(12%) and Salmonella typhimurium was 1(1%). Salmonella typhi was found to be highly sensitive to amikacin (100%), amoxicillin+calvulanic acid (100%), cefotaxime (100%), ceftriaxone (100%), cefuroxime (100%), aztreonam (100%), meropenem (100%), piperacillin-tazobactam (100%), cefixime (90.48%), gentamycin (90.48%), ceftazidime (85.71%), ciprofloxacin (85.71%) and nalidixic acid (85.71%). S. typhi was found to be less sensitive to trimethoprim-sulphamethoxazole (23.81%) and ampicillin (23.81%). Conclusion: S. typhi is still the major cause of enteric fever in our region but the emergence of more antibiotic susceptible strains may help clinicians in the treatment of this disease to reduce the morbidity.

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