Muhammad Munir Ahmed, Rahat Sarfraz, Mamoona Naheed, Saeed Ahmed, Zahid Ibrahim, Muhammad Farooq.
Morphological Changes in Cerebellum of Albino Mice by giving lead: An experimental study.
Pak J Med Health Sci Jan ;6(3):547-8.

Effects of lead on brain morphology of albino mice were seen in this study. Sixty albino mice were divided into five groups. Group 0 was scarified after first week for baseline morphology. Group I, (normal control) was fed on synthetic diet, group II, III and IV were given lead acetate 2 mg, 4 mg and 8 mg/kg/day respectively for 60 days. H&E and Rhodizonate methods were performed for histological examination. Cerebellum of albino mice revealed increased oedema, congestion and neuronal changes (pyknosis) in group II. Group III and IV showed moderate changes in all the parameters of albino mice cerebellum. Rhodizonate stain did not show lead deposition in mice cerebellum at these blood lead levels. Low levels of lead toxicity showed brain changes due to its sensitivity.

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