Umer Iqbal, Khawar Ali, Ahsan Khan, Fareeha Sheikh, Fuad Shafique.
The Effect of Bolus Dose of Ephedrine on the Onset Time of Vecuronium.
Pak J Med Health Sci Jan ;6(4):1038-42.

Objective: To evaluate the effect of ephedrine on the onset time of vecuronium Study design: Interventional experimental study. Setting: Department of Anesthesiology, Bhatti International Hospital attached to Central Park Medical College, Lahore Duration of study: Study was carried out over a period of six months from 22-1-2012 to 21-7-2012. Materials and methods: Sixty adult male patients presenting for general surgical procedures under general anesthesia in the operation theatre of Bhatti international hospital were allocated into two groups using random number table. 30 patients each group (ephedrine group and saline group). Results: Mean age was observed 35.5±4.3 and 35.9±5.2, in group A and B, respectively. Excellent intubating conditions were in 15 patients (50.0%) in group-A, and 10 patients (33.33%) in group B while good intubating conditions found in 15 patients (50%) in group A and 17 patients (56.7%) in group B. poor conditions were found in 3 patients (10%) in group B. ASA classification showed 20 patients (66.7%) in group A and 18 patients (60%) in group B belong to ASA-I, while 10 patients (33.33%) in group A and 12 patients (40%) in group B were ASA-II. Mean values of onset time 120.0±9.6 and 170±27.1 in group A and B, respectively. The difference between two groups was statistically significant (P<0.001). Conclusion: Ephedrine 70ug/kg given before the induction of anesthesia improved intubating conditions at 2 min after vecuronium by increasing cardiac output without significant adverse hemodynamic effects.

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