Ashraf Zia, Abaidur Rehman, Razia Ashraf, Taifurul Islam Gilani.
Effect of Magnesium Sulphate on the Dose Requirement of Atracurium.
Pak J Med Health Sci Jan ;6(4):1010-2.

Objective: To compare the mean intraoperative consumption of Atracurium with and without intravenous administration of Magnesium sulphate in patients undergoing elective abdominal surgery under general anaesthesia. Study design: Randomized controlled trial. Setting: Department of Anaesthesia, Services hospital, Lahore. Duration of Study: Six months (1st July, 2011 to 31st December, 2011). Material and methods: One hundred patients of elective abdominal surgery were divided into two groups, group S (control) and group M (Magnesium) comprising of 50 patients each. Magnesium group received Magnesium sulphate 50 mg/kg administered as a slow intravenous bolus and 15 mg/kg/hr by continuous intravenous infusion. The same volume of isotonic saline was administered to the control group. Neuromuscular block was monitored using train-of-four stimulation. Atracurium bolus of 0.15 mg/kg was repeated when more than two responses were detected until the start of closure of peritoneum. Magnesium sulphate infusion was stopped after skin closure. Results: Out of 100 patients, in group S 6(12%) were males and 44(88%) were females while in group M, 12(24%) were males and 38(76%) were females .age was between 25-45 years when compared, the dose of Atracurium in Control group with that of Magnesium group statistically, the difference was significant (P<0.05). Conclusion: The administration of Magnesium led to a significant reduction in the dose of Atracurium used during general anaesthesia.

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