Tahir Nazeer, Riaz Hussian, Maqsood Ali, Tahir Mehmood, Muhammad Younis, Tahir Hameed Dar, Amna Tahir.
Haemodynamic Changes during Induction; Comparison of Propofol with Mixture of Propofol-Ketamine.
Pak J Med Health Sci Jan ;6(4):1006-9.
The objective of this study was to compare haemodynamic changes during induction of general anaesthesia with propofol and mixture of propofol-ketamine. That was Quasi experimental study. One hundred patients undergoing surgical procedure were included and divided into two equal groups A and B by using random number table. Each group comprised of fifty patients. In group A propofol was used as an inducing agent, dose 2.5mg / kg intravenously with in 30 seconds. In group B propofol 2.5 mg/kg and ketamine 2 mg / kg intravenously within 30 seconds. No other drug like muscle relaxants and analgesics were given to patients. Only 100% O2 given to patient with face mask. Heart rate, systolic and diastolic blood pressure were recorded for three minutes at the interval of 30 seconds. Students “t” test was used and analysis with SPSS version 10. Significant decrease in systolic, diastolic blood pressure and heart rate was recorded with propofol and minimal haemodynamic changes were recorded with propofol-ketamine mixture.
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