Sobia Qazi, Shahbaz Piracha, Faisal Masud, Saadia Shahzad, Umer Farooq.
The Effect of Colchicine on Thrombocytopenia in Dengue Fever.
Pak J Med Health Sci Jan ;6(4):998-1002.
Objective: To study the effect of colchicine on platelet counts in patients with Dengue fever and to compare the effects of colchicine with placebo. Material & methods: A randomized-control trial was conducted during a dengue fever out break at Services Hospital, Lahore. The total study duration was from November 3rd, 2010 till November 24th 2010. 212 Volunteers aged 14-70 participated according to inclusion criteria. The institutional review board approval was obtained. Group A received oral soda bicarbonate every twelve hours for 72 hours; Group B received oral colchicine, 0.5 mg every twelve hours for 72 hours. Platelet counts were checked on day 0, after 24 hours (day 1), and then for 3 consecutive days. End points were a platelet count rise above 150,000 or fall below 40,000 Results: The rise in mean platelet counts from the baseline at day 0 and at days 1, 2, 3 and 4 were statistically insignificant between the placebo and colchicine groups: p value; 0.679, 0.734, 0.502 and 0.502 respectively. The endpoints of platelet rise above 150,000 and fall below 40,000 were statistically insignificant between the groups: p value; 0.182 and 0.478 respectively. Conclusion: Colchicine does not increase platelet counts in dengue fever.
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