Sayyada Humaira Masood, Abdul Shakoor Memon, Tazeen Abbas, Sayyada Namrah Hassan, Syed Muhammad Masood Ali.
Study to Compare Serum Visfatin Concentration in Different Trimesters of Pregnancy.
Pak J Med Health Sci Jan ;6(4):907-11.

Aim: To compare serum visfatin level in different trimesters of pregnancy and to explore the use of serum visfatin as a predictor of insulin resistance and hence gestational diabetes mellitus. Study design: A cross sectional comparative study Study duration: from April 2010 to September 2012 Place: This study was carried out in the department of Physiology BMSI- JPMC in collaboration with Abbasi Shaheed Hospital Karachi. Patients and methods: 88 women were included in the study, divided into four groups. All women underwent anthropometric variables, metabolic parameters and serum visfatin evaluation. Homeostasis mathetical model assessment (HOMA-IR) and quantitative insulin sensitivity check index (QUICKI). Results: Maternal serum visfatin concentration gradually increased during pregnancy as compared to non pregnant normal weight control women. We also observed a progressive increase in insulin resistance and decrease of insulin sensitivity during pregnancy. Maternal weight, BMI and body fat percentage also increased gradually. Conclusion: It was concluded that insulin resistance in normal pregnancy seems to increase throughout 2nd and 3rd trimesters. Adipose tissue derived visfatin increases in pregnancy to compensate for insulin resistance by its insulin mimetic properties.

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