Arshad Iqbal Gardezi, Muhammad Ayub, Qazi Masroor Ali, Ehsanullah, Muhammad Farooq.
Thyroid Autoantibodies in Chronic Hepatitis C Patients Treated With Interferon Alpha Therapy.
Pak J Med Health Sci Jan ;6(4):860-2.
The aim of study is to study the thyroid auto antibodies in chronic hepatitis C patients treated with interferon alpha therapy. 70 cases of chronic hepatitis C disease were selected for the study. They were divided into two groups Group A included 35 patients of chronic hepatitis C with positive HCV, RNA on PCR who have received 06 months combined therapy of interferon alpha and ribavirin. Group B included 35 patients of chronic hepatitis C with positive HCV RNA on PCR, not taking any therapy. The subjects were selected from different hospitals. Biochemical parameters i.e. Anti-TG antibodies and anti-TPO antibodies were done by commercially available kits by ELISA methods. Sign test is applied for the level of significance. Following conclusions are drawn: Females are more prone to develop thyroid dysfunctions i.e. 4/35 (11.5%) as compared to males. Anti-TPO antibodies were increased i.e. 03/35 (8.6%) in hepatitis C patients after interferon and Ribavirin Therapy. Anti-TG antibodies were increased i.e. 02(5.7%) in hepatitis C patients after interferon alpha and Ribaviirin Therapy.
PakMediNet -Pakistan's largest Database of Pakistani Medical Journals - http://www.pakmedinet.com