Muhammad Shafiq, Muhammad Akram.
A cross sectional study to compare the specificity of creatine kinase MB (CK-MB), cardiac troponin T (ctnt) and cardiac troponin I (ctni) to rule in acute myocardial infarction.
Ann King Edward Med Uni Jan ;18(3):305-8.

Background: Distinguishing whether a patient pre-senting with chest pain has acute myocardial infarction (AMI) or non-cardiac problem is at times difficult. Ruling out AMI requires a test with high diagnostic sensitivity, whereas ruling in AMI requires a test with high diagnostic specificity. This study was planned with the aims and objectives to find out the better mar-ker for the identification of acute myocardial infarc-tion. Methods: The study population consisted of 70 pati-ents. Patients from both sexes, with clinical history of typical chest pain for more than 30 minutes in duration with evidence of acute changes of myocardial infarct-ion on ECG were included in the study. This study was conducted to compare the sensitivity of creatine kina-se – MB (CK – MB), cardiac troponin T (CTnT) and cardiac troponin I (CTnI) for detection of AMI. Data analysis was performed with Statistical Package for Social Sciences 11.5 (SPSS 11.5). Results: The sensitivity of CK – MB was 100% and 17.78% as compared to CTnT and CTnI respectively. The sensitivity of CTnT was 46.67% and 38.10% as compared to CK-MB and CTnI respectively while the sensitivity of CTnI was100% as compared to both CK – MB and CTnT. Conclusion: It is concluded that CTnI is the pre-ferred, dependable and cost effective serum markers for detection of AMI as compared to CTnT and CK-MB.

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