Nabeela Naeem, Muhammad Ayyub, Fazalur Rehman.
Assessment of factor VII levels in patients of chronic liver disease.
J Rawal Med Coll Jan ;17(1):25-7.

Background : To determine the levels of coagulation factor VII in patients of chronic liver disease. Methods: In this descriptive study sixty known patients of chronic liver disease were included. Patients were stratified into three groups on the basis of Child-Pugh scoring system, utilizing ascities, bilirubin, albumin, prothrombin time and encephalopathy as marker of disease activity. The correlation of Child-Pugh scoring system with factor VII levels was analyzed. Results: Majority ( 63.33%) were males . Mean age was 50.5 years. Majority of patients (82%) had deficient Factor VII levels. Factor VII levels revealed a declining trend from Child-Pugh class B to C. Conclusion: Due to its short half-life factor VII level can serve as a helpful marker in diagnosing the degree of liver damage and as a prognostic indicator during the course of treatment.

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