Ifra Saeed, Iram Iqbal, Rehmah Sarfaraz, Khadija Qamar, Shadab Ahmed Butt, Saffia Shaukat.
Histomorphological changes in placentae of pre- eclamptic mothers with reference to vasculosyncytical membrane thickness and syncytial knot formation.
J Rawal Med Coll Jan ;16(1):51-4.

Background: To study the histomorphological changes in placentae of pre-eclamptic mothers and to compare them with placentae of normotensive mothers. Methods: In this comparative study, hundred placentae were taken and divided into two groups. Normotensive group included placentae from mothers having normal blood pressure and hypertensive group included placentae from mothers having pre-eclampsia. Placentae were fixed in normal saline for 48 hours. After fixation the placentae were divided into four quadrants and 5mm tissue was taken from the center of upper right and lower left quadrants. After tissue processing and staining, the histomorphological changes were studied in both normotensive and hypertensive groups. Results: The number of terminal villi were increased in hypertensive group. The quantitative difference between number of syncytial knots and villous membrane thickness in normotensive and hypertensive groups was statistically significant . Conclusion: Increased number of syncytial knots was observed along with increased thickness of vasculosyncytial membrane in hypertensive group as compared to normotensive group that may be the cause or effect of placental hypoxia.

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