Muhammad Irfan Safi Rizvi, Nargis Anjum, Akber Ali Khoja.
Serum Cystatin-C: A better predictor of decreased Creatinine Clearance than serum Creatinine in cancer patients on Cisplatin.
Ann Abbasi Shaheed Hosp Karachi Med Dent Coll Jan ;7:278-85.

Objective: To observe the effects of acute deterioration in GFR, induced by cisplatin, on the levels of serum creatinine and cystatin C and to correlate the level of serum creatinine and cystatin C among cancer patients and the controls. Design: It is a comparative study carried out in the Department of physiology, Basic Medical Sciences Institute, Jinnah Postgraduate medical Centre, Karachi. Subjects: Seventy subjects were included in the study. Group I comprising of cancer patients with GFR greater than 80 ml/min/1.73m2 and group II comprising of cancer patients with GFR less than 80 ml/min/1.73m2. Estimations of serum creatinine, urinary creatinine and cystatin C in all subjects were done twice, first before the start of chemotherapy with cisplatin and second before the start of second cycle. Result: A highly significant correlation was found between the reciprocals of the levels of cystatin C and creatinine clearance as compared to a less significant Pvalue, which was found between the reciprocals of the levels of creatinine and creatinine clearance. Conclusion: In conclusion, the results of this study emphasizes that serum cystatin C is a promising endogenous marker of GFR, and it might be of particular interest in patients with slightly decreased renal functions.

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