Saffia Shaukat, Shabana Ali, Fatima Riaz.
Effects of Lead Toxicity on Spermatogenesis in the Testes of Albino Rats.
J Islamic Int Med Coll Jan ;6(1):33-6.

Objective: The objective of this study was to observe changes in spermatogenesis in the testes of albino rats exposed to lead acetate. Study Design: An experimental animals study Place of Study and Duration: This study was carried out in the Department of Anatomy, Islamic International Medical College Rawalpindi and at National Institute of Health Islamabad from January to April, 2009. Materials and Methods: Male adult rats were exposed to lead acetate with intraperitoneal dose of 4mg/Kg body weight for 5 days a week for 6 weeks. The animals in group A were used as control. The animals of groups B were treated with lead acetate with specified dose for 6 weeks. After 6 weeks the animals of subgroup B were sacrificed. The results of these two groups were then compared. Results: After six weeks, it was observed that the number of spermatogenic cells had decreased in the test groups as compared with control group (p<0.05). Conclusion: Lead is toxic for cells of spermatogenic series, injurious to heaith and plays a significant role in reducing male fertility.

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