Anis Hussain Jafri, Aziz Abdullah, Saba Jamal.
A rare case of the small cell neuroendocrine carcinoma of urinary bladder.
J Bahria Uni Med Dental Coll Jan ;3(2):93-5.

Abstract: Small cell neuroendocrine carcinoma of urinary bladder (SCCB) is a rare, prevalent in males, highly aggressive carcinoma being diagnosed usually at advanced stages. The origin of the disease is unknown; however the multipotent stem cell theory applies best to this case. Histology and immune histochemistry shows a tumor which is indistinguishable from small cell lung carcinoma (SCLC). We report a case of SCCB in a 70 year old female who presented with history of recurrent urinary tract infections and hematuria for six months. CT scan showed a large mass in bladder, infiltrating muscle along the left lateral wall with no extra-vesical extension. Cystoscopy revealed a muscle invasive mass protruding into the bladder lumen, extending from 3-5 o’clock. Initial histopathology showed poorly differentiated urothelial neoplasm. She underwent an uneventful radical cystectomy with urinary diversion to ileal conduit. Final histopathology revealed SCCB. Patient is followed up in the oncology department

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