Santosh Kumar, Abdul Mananjunejo, Bhagwan Das, Shafique-ur-rehman Memon, Rafique Ansari, Jai Pal Paryani.
Focal segmental glomerulosclerosis in adults.
Isra Med J Jan ;6(3):133-5.

OBJECTIVE: To discover the burden of focal segmental glomerulosclerosis in patients of nephrotic range proteinuria (i.e.>3.5gm/24 hours/ 1.73m body surface area) STUDY DESIGN: A case series study PLACE & DURATION: At the department of Nephrology Jinnah Post Graduate Medical Centre from 1st May 2011 to 30th Nov 2011 METHODOLOGY: Patients with nephrotic range proteinuria diagnosed by 24 hours urinary protein (>3.5gm/24 hours/1.73m BSA) were included. Serum creatinine, total proteins, serum albumin, 24 hour urinary proteins, creatinine clearance, coagulation profile as well as renal biopsy was performed in every patient. In renal biopsy <50% glomerular involvement with involvement of a portion of the glomerular tuft was confirmed as patients having the focal segmental glomerulosclerosis. RESULTS: The mean age of the patients was 25.93 ±5.923 years. Out of 144 patients there were 38(26.38%) females and 106(73.31%) males. There were 67 (46.5%) patients with focal segmental glomerlusclerosis with nephrotic range proteinuria. CONCLUSION: The burden of focal segmental glomerulosclerosis in patients with nephrotic range proteinuria is high.

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