Muhammad Waseem Kausar, Inayat-ur Rehman.
Comparison and correlation of hepatic and hematological parameters in patient with plasmodium vivax and plasmodium falciparum.
Isra Med J Jan ;6(3):155-60.

OBJECTIVES: To compare and correlate hepatic and hematological parameters in patients with Vivax and Falciparum Malaria STUDY DESIGN: A retrospective comparative study. PLACE AND DURATION: The study was conducted the Department of Biochemistry, Basic Medical Sciences Institute with collaboration of National Institute of Child Health and malaria control program counter at Jinnah Postgraduate Medical Center Karachi during 1st August 2005 to 31st December 2006. METHODOLOGY: The study included 120 consecutive patients. All patients were between 1 to 10 years of age. They were divided equally into two groups, Plasmodium vivax malaria (Group A) and Plasmodium falciparum malaria (Group B). Those patients having a history of icterus, taking hepatotoxic drugs or had evidence of hepatic dysfunction were excluded from the study. Liver function tests and hematological parameters performed. RESULTS: All patients had fever, chills with rigors and body aches. On evaluation an increasing tendency of jaundice and hepatosplenomegaly along with statistically significant value (p<0.05) in serum bilirubin, alanine transaminase(ALT),hemoglobin, bleeding time (BT) and prothrombin time(PT) was found in patients with Falciparum as compared to vivax malaria. In Group A, serum bilirubin has negative correlation with hemoglobin but positive with PT. PT has negative correlation with ALT but positive with aspartate transaminase (AST). Platelet has negative correlation with ALT but positive with alkaline phosphatase (ALP). In Group B, hemoglobin has negative correlation with bilirubin, ALT and AST but positive with ALP; serum AST, and ALT were negatively correlated with, platelet and PT but positive with bleeding and clotting time. Platelets have significant coefficient correlation (0.524) regarding total protein and clotting time shows significant coefficient correlation (0.606) with alanine transaminase shown in table- 111. CONCLUSIONS: Liver function test and hematological parameters should be performed in patients with diagnosed Plasmodium Falciparum Malarial infection to prevent complication.

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