Ghulam Shah Nizamani, Rashid Ahmed Memon, Asghar Khan, Saeed Sattar Shaikh, Ikram Uddin Ujjan.
Analysis of anti phospholipid antibodies in women with recurrent spontaneous abortion.
Isra Med J Jan ;6(2):78-80.

OBJECTIVES: To analyze antiphospholipid antibodies in women with recurrent spontaneous abortion. STUDY DESIGN: A Case-control study PLACE AND DURATION: Isra University and Liaquat University of Medical and Health Sciences Jamshoro from 1st June to 31st December 2010. METHODOLOGY: Sixty three subjects with history of three spontaneous abortions in their first three months of pregnancy were included in this study and 63 women of corresponding age, with one or more alive babies having no record of any first trimester spontaneous abortion were taken as controls. Coagulation tests platelet count, prothrombin time and activated partial thromboplastic time were done by standard methods. Antiphospholipid Antibodieswere estimated by ELISA method using specific kits. RESULTS: Mean serum Antiphospholipid antibodies level was 7.10+3.47 in patients and 6.30+2.02 in controls. The difference in serum level of two groups was significant. Mean platelet count; mean prothrombin time & activated partial thromboplastin time revealed no significant difference between patients and controls. CONCLUSION: There is strong association of antiphospholipid antibodies in the patients having recurrent spontaneous abortions so there is a strong need of including this test in the primary screening of such disease in the pregnant women who have history of previous abortion.

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