Munazza Asad, Sabeen Haq, Tahir Ahmad Munir, Muhammad Aslam.
Hypoglycemic and anti-platelet aggregatory effect of acacia modesta leaves extract on alloxan induced diabetic rats.
Isra Med J Jan ;5(3):176-9.

OBJECTIVES: To compare the hypoglycemic and anti-platelet aggregation effect of Acacia modesta leaves extract and Glibenclamide on alloxan induced diabetic rats. STUDY DESIGN: Experimental study PLACE AND DURATION: This Experimental study was performed at Shifa College of Medicine and National Institute of Health (NIH), Islamabad. METHODOLOGY: Diabetes mellitus was induced in 90 out of 120 male albino rats by intraperitoneal injection of 110 mg/kg bw of alloxan and was confirmed by measuring fasting blood glucose level >200 mg/dl on 4th post-induction day. The rats were equally divided into four groups, A (normal control), B (diabetic control), C (diabetic rats treated with glibenclamide), and group D (diabetic rats treated with plant extract). Rats of group C& D were treated with single dose of 900 μg/kg b.w of glibenclamide and 400 mg/kg b.w of Acacia modesta leaves extract respectively for three weeks. Blood Glucose levels were measured by glucometer, Platelet aggregation by Dia-Med and serum beta-thromboglobulin by ELIZA technique. RESULTS: The results showed significant hypoglycemic (p<0.01) and anti-platelet aggregatory (p<0.01) effect of glybenclamide and Acacia modesta leaves extract on diabetic control rats. Within the treatment groups, the fasting blood glucose, and serum betathromboglobulin levels were nearly equally significant (p<0.05) in diabetic rats treated with glibenclamide and plant extract. CONCLUSION: Acacia modesta leaves extract has a nearly equally significant hypoglycemic and anti-platelet aggregation effect on diabetic rats as that of glybenclamide.

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