Muhammad Javed Masood, Aamir Ali Khan, Khalid Usman, Humaira Zafar, Zahid Iqbal, Tasneem Zarfishan, Mohi Ud Din Mudassir.
Association of smoking and low serum bilirubin antioxidant concentrations.
Isra Med J Jan ;5(3):193-4.

OBJECTIVES: The objective of this study was to identify the association between cigarette smoking and serum bilirubin antioxidant concentrations. STUDY DESIGN: A descriptive cross sectional study PLACE AND DURATION: Study was conducted at the Department of Biochemistry at Sheikh Zayed hospital Lahore over a period of one year from January 2012 to December 2012. METHODOLOGY: The sample size was sixty with an equal distribution of healthy and control group. Thirty were known smokers and thirty were healthy controls. Thirty smokers who had been smoking for at least five pack years (20 cigarettes per day for one year is equal to one pack year) were included after ruling out coronary artery disease by Exercise Tolerance Test. Same no. of healthy control subjects were selected from general population with no history of smoking, CAD, Diabetes and hypertension. RESULTS:The results of the study have shown that smoking decreases the serum bilirubin concentrations. The mean value of serum bilirubin in 50%(n=30) smokers was 0.59 + 0.034. While in control group 50%(n=30), it was 0.85 + 0.057. CONCLUSION: From the results, it was concluded that cigarette smoking lowers the bilirubin antioxidant concentration.

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