Rukhsar Ali Shahani.
Chloroquine resistant plasmodium falciparum malaria in flood victims of district Dadu, Sindh.
Isra Med J Jan ;5(2):127-9.

OBJECTIVES: To determine the frequency of Chloroquine-resistant (CQR) Plasmodium falciparum in flood victims. STUDY DESIGN: Descriptive study PLACE AND DURATION: Flood camps of District Dadu from May – October 2012. METHODOLOGY: Eighty patients with P.falciparum positive on thick and thin blood film were studied. The WHO extended test was done by giving 25 mg/kg body weight of Chloroquine base over 3 days. The interpretation of the test was done as per criteria laid down by WHO. Thick and thin blood slides of all subjects recruited were obtained on days 1,2,3,7,14,21,28 for monitoring the course of asexual parasitaemia. RESULTS: Out of eighty patients, 56.2% (n=45) were males and 43.7% (n=35) were females. Male to female ratio was 1.2:1. The age range was 19-56 years with means (±SD) 39±11 years. 47.5% (n=38) were Chloroquine sensitive. Chloroquine-resistance (CQR) RI, RII & both RI RII noted were 33.7%, 18.7% and 52.4% respectively. CQR- R III was not observed in our present study. CONCLUSION: We found high frequency of Chloroquine resistance in Plasmodium falciparum malaria in flood victims. However, further studies are recommended to estimate the prevalence of chloroquine resistant falciparum malaria.

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