Neem Kousar, Muhammad Tayyab, Allah Ditta, Farrukh Kamal, Saqib Naseer Chaudhary.
Serum Immunoglobulin G Levels in Graves` Disease Patients at Various Stages of Antithyroid Therapy.
Ann King Edward Med Uni Jan ;8(1):5-7.

Thirty six patients with Graves` disease (GD), diagnosed on the basis of clinical examination and appropriate laboratory tests were classified into three groups (A-C): Group A: twelve newly diagnosed Graves` disease patients; Group B: twelve hyperthyroid Graves` disease patients on antithyroid drug therapy and Group C: twelve Graves` disease patients who had been rendered euthyroid with antithyroid drug (ATD) therapy. Serum IgG was determined by radial immunodiffusion method using commercially available kits (The Binding Site UK). The mean IgG in newly diagnosed patients with GD (Group A) was 18.78±1.81. It was 22.75±1.89 in hyperthyroid GD patients on drug therapy (Group B), 14.3±0.8 in GD patients who were rendered euthyroid with drug therapy (Group C) and 11.85±0.72 in normal controls. The IgG level of group A patients were not significantly different from those of group B. However, the levels of IgG and IgA were significantly low in group C Graves` disease patients as compared to group A patients. A significant reduction in IgG level in Graves` disease patients who were rendered euthyroid after antithyroid drug therapy as compared to newly diagnosed Graves` disease patients indicate the immunosuppressive effect of antithyroid drug therapy.

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