Sara Habib, Asad Ali Khan Afridi, Mohammad Wasay, Romaina Iqbal.
Isoflavones and alzheimer’s disease: the effects of soy in diet.
Pak J Neurological Sci Jan ;9(2):40-5.
Pathologically, Alzheimer’s disease is a result of aggregation of amyloid peptides and protein tau in the brain forming neurofibrillary tangles which are highly toxic to neuronal circuits in the brain. Recent evidences report that apart from aging, estrogen deficiency is one of the risk factors predisposing to the development of Alzheimer’s disease. Isoflavones, also known as phytoestrogens, are metabolized by the body forming compounds that are known to interfere with neurotoxic pathways and through their anti-fibrillization effects they play a role in reducing apoptosis of neurons and glial cells and promote axonal regeneration. Experimental studies on transgenic models with Alzheimer’s disease as well as various observational and clinical trials suggest that dietary interventions with Isoflavones may have a significant role in improving portions of memory, cognition and decreasing the risk of Alzheimer’s disease.
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