Aisha Taj, Zehra Naqvi.
Eff ect of metformin therapy in patients with Polycystic Ovary Syndrome.
Pak J Surg Jan ;26(1):65-9.

Objective: To determine the eff ect of 12 week of metformin therapy on clinical and hormonal indices of patients with Polycystic Ovary Syndrome. Study design: Prospective Study sett ing: Th e study was carried out at the outpatient Department of Obstetrics & Gynaecology and Endocrinology from Sept. 2006 to April 2007. 30 women meeting the eligibility criteria were enrolled. Th ey were interviewed using standardized proforma . Data was analyzed by using SPSS version 10. Paired t- test was used for comparison. Intervention: Patients were treated with 500mg of tab.metformin three times daily for 12 weeks. Main outcome measures: Hirsuitism, menstrual irregularities, BMI and fasting insulin levels were assessed before and aft er treatment . Results: In 21 of 30 patients(70%) normal menstrual cycle resumed. Th ere was signifi - cant reduction in the BMI (p< 0.000), and signifi cant reduction in the fasting insulin Levels (p<0.000). 73.3% presented with hirsuitism and 33.3% showed improvement. Conclusion: 12 week course of metformin is eff ective in the treatment of menstrual irregularities ,in reducing weight, fasting insulin levels and improving hirsuitism.

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