Mehmooda Wasim, Syed M Shafqatullah, Anis Subhan.
Role of intraperitoneal bupivacaine in laparoscopic cholecystectomy.
Pak J Surg Jan ;30(3):222-6.

Objective: To compare the mean pain score through Visual Analogue Scale in patients undergoing laparoscopic cholecystectomy with and without intraperitoneal bupivacaine. Study design: Randomized controlled trial. Place and duration of study: General surgery department , Ward 3 JPMC Karachi from March 2011 till June 2011 for a period of about three months. Methodology: Total ninty eight patients were selected for the study. Patients were admitt ed through OPD. Two were exempted from the study . Both groups have 49 patients.Group A patients received 20 ml of 0.5%ofi ntraperitoneal bupivacaine while Group B patients did not receive intraperitoneal bupivacaine. Th e anesthetic technique was standardized for the two groups.Th e degree of postoperative pain was assessed using Visual Analogue Scale at 4,8,12 and 24 hours aft er the surgery. Th e results were analyzed on SPSS version 15. Results: Th e mean pain scores were lower in group A than in group B at rest. Consumption of analgesics was also lower in patients of group A(28%) while it was 71% in patients of group B.Th e incidence of abdominal pain was signifi cantly lower in patients receiving intraperitoneal bupivacaine. Mean VAS pain scores from 4-24 hrs postoperatively of group A was 0.90± 0.51 with 95 % confi dence interval while in group B it was 0.96±0.90 with 95 % confi dence interval. Conclusion: Instillation of 20 ml of 0.5%of intraperitoneal bupivacaine aft er removal of gall bladder in laparoscopic cholecystectomy off ers good analgesia.

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