Nasreen Naz, Mehria Khan.
Diagnostic accuracy of C.T scan in retinoblastoma.
Pak J Surg Jan ;29(3):199-204.

Objective: To determine the diagnostic accuracy of computed tomography in evaluation of retinoblastoma keeping histopathology as gold standard. Study design: Cross-sectional validation study Duration of study sett ing: Th e study was conducted at Radiology department of Postgraduate Medical Institute (PGMI) Hayatabad Medical Complex Peshawar from January 2011 to May 2011 and Civil Hospital Dow Medical College Karachi from October 2011 – April 2012 and Patients and Methods: In this cross sectional validation study a total of 54 numbers of cases presenting with proptosis were enrolled. Th ese patients referred to the Radiology Department at Civil Hospital Karachi and PGMI of Hayatabad Medical Complex for C.T scan. Patients under 05 years of age of both genders having proptosis were included in the study. Diagnosed and follow-up cases for retinoblastoma, patients above 05 years of age, patients with thyrotoxicosis and simulating lesions like coats disease were all excluded from the study. All CTs were reported by the expert and senior radiologist of the department. CT results assess for the presence of intraocular mass with calcifi cation and extent of the disease with and without involvement of optic nerve. All observations were properly recorded and the biopsies performed by experts and results were followed. Data was entered and analyzed using SPSS version 15.0 soft ware. Th e study outcome was determined in terms of diagnostic accuracy of CT in retinoblastoma keeping histopathology as gold standard. Results: A total of 54 patients were enrolled. Th e mean age of patients was 3.6 + 1.2 years. Male gender was predominant while 24.0% patients were females. According to analysis CT had 91.4% sensitivity and 71.3% specifi city while the positive and negative predictive values were 97.7% and 20.0% respectively. Conclusion: Based on our study fi ndings it is concluded that CT imaging has a high sensitivity and a reasonable specifi city in the detection of calcification and assessment of Retinoblastoma at earlier stage which is confi rmed by histopathology. CT has a sensitivity and specifi city of 91.4% and 71.3% in detecting retinoblastoma in the current study so it is bett er not to do histopathology and treated on the basis of C.T report.

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