Khaleel M E, Raza A, Ehsan A, Masood R, Javed M.
Clinicopathological spectrum of oral squamous cell carcinoma at a public sector health facility.
Biomedica Jan ;31(1):21-6.

Background: Oral epithelial cancer is one of the most common malignant diseases in the world. Over 90% of the oral cancers are oral squamous cell carcinomas (OSCC), which arise from epithelial lining of oral cavity. It is the second most frequent cancer in Pakistan. The aim of this study was to assess the demographic and clinicopathological features of oral cancer patients reporting to Department of Pathology at Post Graduate Medical Institute, Lahore, Pakistan. Methods: This cross – sectional descriptive study was done from January 2013 to December 2013. Demographic, clinical and pathological details of cases diagnosed with oral squamous cell carcinoma were collected. Anneroth et al, multifactorial grading system was used to perform histological grading. SPSS version 19.0 was used to analyze the data. Results: Of the total 57 cases majority of patients were in their 4th and 5th decades of life with male predilection as male to female ratio was 1.3:1. Major risk factors reported were smoking (n = 33) and chewing tobacco (n = 18). Majority of oral cancer cases were seen in age group 41 – 50 year. Buccal mucosa was the most commonly affected site followed by tongue. The most common clinical complaint was ulceration and well differentiated sqaumous cell carcinoma appeared as the major histopathological type. Conclusions: Oral cancer is a common malignancy in Pakistan with tendency of developing among males and at an early age. This study lays emphasis on awareness about the role of various risk factors such as tobacco and related products.

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