Iftikhar Ejaz, Asif Siddique, Ahsan Waheed Rathore, Humayun Iqbal Khan.
Hypertonic Saline (3%) vs Normal Saline (0.9%) Nebuliztion for Acute Viral Bronchiolitis: A Randomized Control Trial.
Pak Paed J Jan ;39(4):248-51.
Objective: To determine mean reduction in respiratory score in patients of acute bronchiolitis with hypertonic saline (3%) and normal saline (0.9%). Study Design: Randomized controlled trial. Setting & Duration: Emergency and in Department of Pediatric Medicine, The Children’s Hospital and Institute of Child Health, Lahore, Pakistan, From October 2013 till March 2014. Intervention: Nebulization of patients with 3% hypertonic saline (3cc) or normal saline (3cc) at 6 hourly intervals and recording the mean reduction in respiratory score after 24 hours. Results: Baseline characteristics were similar in both groups. Comparison of respiratory score in both groups was done which shows that before treatment it was 6.13+0.82 in Group-A and 5.68+0.73 in Group-B, p value was calculated as 0.011. After treatment it was calculated as 2.9+0.84 in Group-A and 3.63+0.84 in Group-B, p value was calculated as 0.002. Reduction of respiratory score was calculated as 3.23+1.17 in Group-A and 2.05+0.50 in Group-B, p value was calculated as 0.000, which shows a significant difference in both groups. Conclusion: Mean reduction in respiratory score was significantly higher in patients of acute bronchiolitis treated with hypertonic saline(3%) as compare to normal saline (0.9%).
PakMediNet -Pakistan's largest Database of Pakistani Medical Journals - http://www.pakmedinet.com