Khurshid Ahmed Abbasi, Arbab Ali Junejo, Haresh Chand, Afsheen Abbasi, Saba Abbasi.
Pathogens and their Drug Sensitivity Pattern in Neonatal Sepsis at A Tertiary Care Hospital Larkana.
Pak Paed J Jan ;39(4):222-6.

Background: Neonatal Sepsis is leading cause of neonatal mortality world wide. Gram-ve Pathogens are commonest cause of neonatal sepsis in developing countries, whereas Streptococcus group B in Europe and North America and these organisms have developed drug resistance to commonly used drugs. Objective: To determine the common pathogens and their drug sensitivity patterns causing neonatal septicemia in Larkana. Methodology: This prospective analytical type of study was carried out in Larkana from Jan 2011 to Dec 2014. All suspected cases of neonatal sepsis who had not received antibiotics before admission were included in the study. Blood culture were taken and sent to laboratory for identification of organism and their drug sensitivity. Variables like age at presentation and sex were also seen. Statistical analysis done by using SPSS version 16. Results: Two hundred ninety two cultures were taken, 152 (52%) were cultures +Ve. Mean age of presentation in early onset sepsis (EOS) was 3.9 + 1.6 days and 17.4 + 6.3 days in late onset sepsis (LOS). Males were predominant in both groups. E-coli and klebsella were common organisms in early onset sepsis and Staphylococcus aureus in late onset sepsis. E-coli and kleibsella were highly sensitive to Amikacin and Staphylococcuss Aureus to Cefotaxime. Conclusion: From this study it was concluded that, E-coli, Klebsella and Staphylococcus aureus were commonest organisms causing neonatal sepsis. E-coli and Klebsella were highly sensitive to Amikacin and Staphylococcus aureus to Cefotaxime.

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