Naghmana Shaheen, Fatima Tahira, Rizwan Gohar, Nosheen Fatima, Agha Shabbier Ali.
Spectrum of Micro Organisms and Their Sensitivity Pattern in Neonatal Sepsis at a Tertiary Care Hospital.
Pak Paed J Jan ;39(4):198-202.

Introduction: Neonatal Sepsis is one of the common causes of neonatal mortality and morbidity in developing countries. It is estimated that 20% of all neonates develop sepsis, and it is responsible for 30-50% of total neonatal deaths, directly or indirectly, in developing countries. Objective: To determine the frequency of bacteriological agents of neonatal sepsis in a tertiary care centre and to determine their pattern of culture sensitivity. Study design: Cross sectional descriptive study. Place and duration of study: The study was conducted from June to December 2012 at neonatal ICU, department of pediatrics Lahore General Hospital. Sampling Technique: Non-probability: Purposive Results: In this study total 320 cases were studied. Blood cultures of all these cases were sent for culture of micro organisms. Out of 320 cases, 51.25% were males and 48.75% female babies. 64% (205) were premature while 36% (115); were full term babies. out of 320 blood samples sent to microbiology lab total 90 cultures were positive (28%). 256 (80%) had early onset (before 7th day) and 64 (20%) had late onset sepsis. In positive cultures, Pseudomonas was most occurring bacteria 43% and most of these strains were sensitive to Piptaz, Meropenum, Amikacin and Ceftazidime. Other isolated organisms were E.Coli 14.4%, Klebsiella 12%, Staph aureus 11%,Candida 7.8% and acinobacter 6.6%. Conclusion: Isolates in high number of organisms like pseudomonas aeruginosa, Candida, and acinobacter depicts higher incidence of nosocomial infections in labor rooms , nurseries and NICUs of tertiary care hospitals. it stresses upon the need of highly skilled as well as high powered infection control committee in these hospital.

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