Muhammad Adnan Saeed, Riaz Ahmad, Kirn-emuneera Rabbani.
Effects of Previous Overt Hyperthyroidism due to Graves’ Disease on Bone Mineral Density (BMD) in Euthyroid Pre and Post Menopausal Females.
J Rawal Med Coll Jan ;19(2):124-8.

Background: To determine the effects of previous overt hyperthyroidism due to Graves` disease on BMD in euthyroid pre and post menopausal females. Methods: In this cross-sectional, noninterventional study,fifty patients with previous hyperthyroidism due to Graves` disease (premenopausal:25, postmenopausal: 25) who remained euthyroid for at least 6 months prior to study were included and compared with fiftymatched respective controls. Free thyroxine (FT4), TSH, and BMD were measured. Comparison was made between two groups and also between patients and controls in each group. Results: Statistically significant (p <.0.05) lower whole body BMD expressed as Z-score was observed in post-menopausal women having history of hyperthyroidism due to Graves` disease than matched controls. Bone mineral density, expressed as Z-score in whole body and lumbar spine was significantly lower in group II (post-menopause) in comparison to group I (pre-menopause) patients. Time of euthyroidism and time of evolution of disease has significant effect on BMD in postmenopausal women. Conclusion: Graves` hyperthyroidism affects BMD only in post menopausal females even after achievement of euthyroid status.

PakMediNet -Pakistan's largest Database of Pakistani Medical Journals - http://www.pakmedinet.com