Muhammad Irfan Khattak, Sohail Sabir, Samina Naseem Khattak, Naila Tahir.
Spectrum of Acute Kidney Injury (AKI) in Pregnancy.
J Rawal Med Coll Jan ;18(2):267-9.

Background: To study various etiological factors associated with acute kidney injury during pregnancy and their outcome Methods: In this cross sectional descriptive study, previously healthy ladies who developed AKI during pregnancy (n=88) were included .AKI was defined as per AKINs criteria i.e. Increase in serum creatinine by > 0.3mg/dl within 48 hours from previously normal base line values or urine volume <0.5ml/kg/h for 6 hours or more was labelled as AKI. These patients were worked up for likely causes of AKI and followed up for up to three months postdelivery. Cases with persistent azotemia for more than three months were labelled as chronic kidney disease Results: Mean age of the patients was 26.3 + 7.06 years. A total of twenty seven (31%) patients presented with AKI in 1st trimester, eleven patients (12%) were diagnosed in second and twenty nine (33%) were diagnosed with AKI in 3rd trimester. During postpartum period 24% developed AKI. Septic abortion was commonest cause of AKI during pregnancy(31.8%), followed by ante partum hemorrhage (14.8%), peri-partum sepsis(10.2%), gastro intestinal fluid losses i.e. diarrhoea and hyperemesis (6.8%), post-partum hemorrhage PPH 10.2%, HUS-TTP 14.8%, acute pyelonephritis 4.5% and hypertensive disorders of pregnancy 6.8% . Conclusion: Multiple factors contribute to AKI in pregnancy.Sepsis is the commonest.

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