Khalil-ur rehman, Nasir Khokhar.
Development of Systemic Lupus Erythematosus Following Interferon-α Therapy for Hepatitis C Infection.
J Coll Physicians Surg Pak Jan ;26(3):223-4.

Interferon-alpha (IFN-α) therapy has been associated with de novo development of systemic lupus erythematosus (SLE). We report a 48-year woman with chronic hepatitis C, who developed low grade fever, joint aches and pains, painful mouth ulcers, shortness of breath, dry cough and pleuritic chest pain after 2 months of completion of treatment with pegylated interferon-alpha. These clinical manifestations and the relevant immunologic investigations were in favour of SLE. She responded well to corticosteroids and hydroxychloroquine treatment.

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