Syed Kashif Abbas, Muhammad Jameel Ashraf, Sana Dawood.
Impact of Pre-eclampsia on Neonatal Outcome at Tertiary Care Center.
Ann Abbasi Shaheed Hosp Karachi Med Dent Coll Jan ;21(3):166-70.

Objective: To determine the impact of pre-eclampsia on neonatal outcome at a tertiary care hospital. Methods: This was a cross-sectional study conducted in the Neonatal Intensive Care Unit (NICU) and High Dependency Unit (HDU) of Liaquat National Hospital over a period of six months, i.e from June 2015 till December 2015. The inclusion criteria includes all neonates born to pregnant women with systolic blood pressure from 130 to 200 mmHg, Diastolic blood pressure of >110mmHg and proteinuria >1 on dip stick or >300mg/l in 24 hour urinary specimen irrespective of gestational age. The exclusion criteria was all babies born to mother with chronic hypertension, glucose intolerance, renal disease, multiple pregnancy, congenitally abnormal fetus or sepsis. Results: A total of 80 babies met the inclusion criteria and were included in our study of which only 39 babies were admitted in NICU. Majority of babies were discharged home. Approximately 48.71 % babies managed to stay for 72 hours. Moreover, the major chunk of babies were delivered moderate to late preterm in the study. A total of 23 out of 39 babies presented with IUGR (Intrauterine Growth Restriction) which constitute about 58.97% of total. Regarding the impact of eclampsia on neonatal hematological profile, 25 (64.10%) developed thrombocytopenia, 8 (20.51%) developed anaemia while 6 (15.38%) were found showing no fluctuation in their haematological profiles. Conclusion: Babies born to pre-eclamptic mothers were found to have higher rates of NICU admissions and longer period of stay compare to those who born to non-eclamptic mothers. Moreover, premature birth and Respiratory Distress Syndrome (RDS) also impose significant risk to newborn babies. Early identification and collaborative approach regarding pre-eclampsia could help us mitigate the poor outcome of neonates born to eclamptic mothers. Keywords: Pre-eclampsia, neonatal outcome, fetal growth retardation and prematurity. IRB: Approved by Research Committee of Liaquat National Hospital and Medical College. Dated: 8th April 2016.

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