Elroy Saldanha, Arnadi Ramachandrayya Shivashankara, Leo Francis Tauro, Ashwin Alva, Joseph Alukal, Ashwin D A Lobo, Sucharitha Sureshd, Muktha Ramesh Paie, Manjeshwarshrinath Baligaf.
Evaluation of antioxidant and cell death status in people with acute appendicitis: a preliminary study.
Pak J Surg Jan ;31(4):227-31.

Objective: Th e present study was conducted to investigate the levels of antioxidant glutathione (GSH), lactate dehydrogenase (LDH) and lipid peroxidation (LPx) in plasma of patients with acute appendicitis. Material and Methods: Blood samples were obtained (n = 34) from people requiring appendectomy (n = 30) and people with normal appendix but requiring gastrointestinal surgery for some other GI diseases and willing for complementary appendectomy (n = 4). Th e levels of GSH, LPx and LDH were evaluated and statistically compared. Additionally, statistical analysis to observe for correlation between these parameters with histological grading and Alvarado scores were also performed. Results: Th e levels of LPx and LDH were higher and GSH was lower in plasma. Negative correlation for GSH and positive correlation for LPx was observed. With respect to LDH positive for plasma was observed with both histopathological and clinical grading. Multiple Regression analysis for the biochemical endpoint in plasma levels showed these parameters to contribute 90.3 and 39.3 respectively towards the histopathological and clinical grading. Conclusions: Th e results from this study indicate that GSH, LPx and LDH may be useful surrogate markers for evaluating the progression, stage and complexity of acute appendicitis.

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