Abdul Jabbar Mirani, Syed Muhammad Maroof, Arif Raza, Muhammad Absar Anwar, Shahid Suleman, Ahmed Kamal.
The role of 10% sucralfate ointment in the reduction of acute postoperative pain after open hemorrhoidectomy.
Pak J Surg Jan ;31(3):153-7.

Background: The purpose of the study was to evaluate the use of 10 % sucralfate ointment in the reduction of acute postoperative pain after open hemorrhoidectomy. Design: This study was a prospective, randomized, placebo-controlled trial. Sett ing and Duration: Th is study was carried out at the Department of General Surgery, Civil Hospital Karachi between January 2014 to December 2014. Methodology: A total of 48 patients (24 men and 24 women) between 20 and 70 years of age who underwent open hemorrhoidectomy were included in this prospective, randomized, controlled trial and were randomly divided into two groups (24 in each group), receiving either sucralfate ointment or placebo immediately aft er surgery and then every 12 h for 14 days. Th e primary outcome measure was pain intensity measured by a visual analogue scale at different time points after hemorrhoidectomy. Results: The sucralfate group had significantly less pain than the placebo group at 24th h and the 48th h after hemorrhoidectomy (4 +/- 1.14 vs 5.08 +/- 0.97; P = 0.001 and 3 +/- 0.72 vs 4.41 +/- 0.8; P=0.001, respectively), and they consumed lower amounts of analgesics at the same time intervals (12.50 +/- 16.48 vs 21.87 +/- 15.30 mg of pethidine; P = 0.047 and 152 =/- 23 vs 172 =/- 29 mg of diclofenac; P = 0.009, respectively). The same trend continued until the end of the trial. Conclusions: The study showed that Sucralfate ointment reduced the acute postoperative pain after hemorrhoidectomy.

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