Humyra Tabasum, Tanzeel Ahmad, Farzana Anjum, Hina Rehman.
The effect of Unani antiacne formulation (Zimade Muhasa) on acne vulgaris: A singleblind, randomized, controlled clinical trial.
J Pak Assoc Derma Jan ;24(4):319-26.

Objective To evaluate clinically the efficacy of Zimade Muhasa, a Unani anti acne formulation, for Busoore labaniya (Acne vulgaris) against 5% benzoyl peroxide. Methods The randomized, single-blind, standard controlled trial of 6 weeks evaluated the efficacy and tolerability of Unani topical antiacne formulation against standard control i.e. 5% benzoyl peroxide in 48 patients of either sex on the basis of Global Evaluation of Acne Scale (GEA Scale) along with arbitrary scale for assessment of effect over postinflammatory hyperpigmentation, scarring and fairness. In addition quality of life was assessed according to Cardiff Acne Disability Index (CADI) questionnaire. The alterations in improvement and possible complications were regularly assessed. Results After 6 weeks of treatment, compared with baseline both the treatment preparations decreased the acne lesions (P<0.001). Further, the test formulation improved postinflammatory hyperpigmentation (P<0.001), scarring (P=0.025) and complexion (P=0.001). There was significant (P<0.001) improvement in the quality of life in treatment groups at the end of study. Conclusion The test formulation was well-tolerated and equivalent to 5% benzoyl peroxide in alleviating acne lesions. Test formulation was also more effectual concerning the effects over scars, post inflammatory hyperpigmentation and fairness. This formulation can be used safely to treat active acne as well as in patients with post acne scarring. The clinical relevance may be clarified by longer duration treatment.

PakMediNet -Pakistan's largest Database of Pakistani Medical Journals - http://www.pakmedinet.com