Afifa Razi, Atif Iqbal, Noor-ul Wahab.
Topical Application of Tocopherol with Corticosteroid in Reducing the Early Signs and Symptoms of Oral Submucous Fibrosis Patients.
Ann Abbasi Shaheed Hosp Karachi Med Dent Coll Jan ;21(2):100-5.

Objective: The aim of this study was to compare the topical application of steroid alone or with combination use of steroid and tocopherol in reducing oral mucositis in Oral Submucous Fibrosis (OSMF), patients. Methods: In Pakistani population a rapidly advancing premalignant condition, Oral submucous fibrosis (OSMF), is present which has deteriorated the quality of life. The study was conducted in Department of Oral Medicine & Diagnosis, College of Dentistry, Ziauddin University Karachi, from December 2013 till July 2015. Randomly selected 76 patients with diagnosed OSMF, with history of chewing areca/betal nut or other similar products, with burning sensation on having spicy ingredient, trismus > 20mm with or without palpable fibrous bands on the buccal mucosa intraorally with rigidity and blanching were included in the study. Total 38 out of 76 patients were given a combination of topical tocopherol application100mg and betamethasone (betonil 0.1%) twice daily and remaining 38 were on topical rinse of betamethasone (betonil 0.1%) alone. OSMF patients were clinically examined to assess the mouth opening and other clinical symptoms during three months and were followed up for next two months. Results: In the amelioration of early signs and symptoms of OSMF topical tocopherol combination with steroid application was found to be significantly efficacious. Objective signs of OSMF were reduced with improved mouth opening in 69.56% (p<0.05) of the cases. Conclusion: This study has shown that tocopherol, appears to be an effective drug in treating the early signs of OSMF. Keywords: Oral mucositis, tocopherol, oral submucous, premalignant IRB: Approved by Ziauddin University Karachi. Dated: 2nd March 2016.

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