Naureen Waseem, Hina Kundi.
Protective effects of garlic extract against lead induced histomorphological changes in mice uterus.
J Uni Med Dent Coll Jan ;6(1):12-6.

OBJECTIVE: The study was conducted to evaluate the protective role of garlic extract on the histomorphology of uterus of mouse exposed to lead acetate in an experimental study. STUDY DESIGN: Laboratory based Randomized Experimental study PLACE AND DURATION OF STUDY: Department of Anatomy, Army Medical College in collaboration with National Institute of health from April`June 2013 METHODOLOGY: Thirty female BALBc mice were selected, used and divided into three groups, A, B and C of 10 mice each; group A served as control and was given normal mouse diet, whereas group B and C were experimental; and were treated with 30mg/kg/daily of lead acetate for 60 days each; group C was, however, concomitantly given 500mg/kg/daily of garlic extract; the treatment was given through oral gavage. Animals were sacrificed and dissected at the end of 60 days. Right uterine horn was processed, embedded and stained for histological study. Qualitative histological parameters were observed including stratification of the lining epithelium and variation in shape of the glands. RESULTS: There was stratification of the lining epithelium of uterus in group B, whereas it was simple columnar epithelium in groups A and C. Variation in the shape of glands was seen in experimental group B. In group C the glands were comparable to those of Group A. CONCLUSION: The lining epithelium and glandular shape was markedly affected in lead acetate treated group which improved when co treated with garlic extract.

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