Muhammad Azam Shah, Bilal S Mohydin, Riaz Muhammad, Ghulam Mustafa Zafar, Madiha Iqbal.
Preoperative c-reactive protein levels and postoperative complications of cardiovascular surgery.
J Cardiovascular Dis Jan ;11(1):5-8.

OBJECTIVE: To determine the correlation between preoperative C reactive protein (CRP) OBJECTIVE and postoperative complication of elective cardiac surgery including systemic inflammatory response syndrome, atrial fibrillation, acute kidney injury, wound infection, shock and death. MATERIAL AND METHOD: TERIAL AND METHOD: This prospective observational study was conducted in Punjab TERIAL AND METHOD: Institute of Cardiology, Lahore. Patients undergoing cardiovascular surgery from September 2012 to January 2013 were included. CRP levels were measured in all patients in the morning on the day of surgery. Patients were categorized as Group A (CRP < 2 mg/dl) and Group B (CRP > 2 mg/dl) and were followed for occurrence of postoperative complications till their stay in the hospital. RESULTS: Out of 149 patients [104 (70%) males and 45 (30%) females] studied; 97 (65.1%) TS: patients had CRP < 2 mg/dl (Group A) and 52 (34.9%) had CRP > 2 mg/dl (Group B). Mean age in Group A was 43.6±13.2 years and in Group B it was 48.9±13.4 years. Overall incidence of death was 3.35 % (n = 5) in our study. Overall systemic inflammatory response syndrome (SIRS) was noted in 81 (54.4 %); 34 (65.4%) from Group B and 47 (48.5%) from group A (p= 0.048). Acute renal failure developed in 26 (50%) patients in group B versus 28 (28.9%) in group A (p= 0.011). Wound infection was observed in 13 (25%) patients in high CRP group and 11 (11.3%) in low CRP group (p= 0.031). Statistically significant difference was not noted in both the groups in terms of atrial fibrillation and shock. The death rate was also similar in both the groups. CONCLUSION: Elevated preoperative CRP levels can predict postoperative complications CONCLUSION like SIRS, acute renal failure and wound infection after elective cardiac surgery. Complications.

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