Kifayat Ullah Malik, Ahmad Masood Akbar, Muhammad Arif Nadeem.
Lipid abnormalities in non obese, non diabetic, hypertensive patients.
J Cardiovascular Dis Jan ;11(2):40-4.

BACKGROUND AND OBJECTIVE: Dyslipidemia and hypertension are among the major contributors in pathogenesis of coronary artery disease and with their coexistence, the risk is not added up, rather it is multiplied. The objective of this study was to determine the frequency of dyslipidemia in non-obese, non-diabetic hypertensive patients and compare it with frequency of the same in non-obese, non-diabetic normotensive subjects. METHODS: This case control study was carried out over a period of 6 months (2008-9) at Services Hospital Lahore, Pakistan. The study included 120 adult individuals of either gender; 40 non-obese, non-diabetic, hypertensive patients and 80 non-obese, non-diabetic, normotensive individuals. Demographic data and dietary habits were recorded for every subject using a questionnaire. Fasting lipid profile and blood glucose was tested for all subjects. All data was compared between the two groups. RESULTS:Hypertensive group had higher values for total cholesterol (TC), low density lipoprotein cholesterol (LDL-C) and triglycerides (TG) and lower value for high density lipoprotein cholesterol (HDL-C) as compared to normotensive group. Abnormalities of TC, LDL-C, HDL-C in men only and TG were more frequent in the hypertensive group (Odds ratio =2.96, 2.67, 4.28 and 4.57 respectively). The abnormality of HDL-C in women was similar in both groups (Odds ratio=1.47). CONCLUSION:Hypertensive individuals are more likely to have various lipid abnormalities i.e., of total cholesterol, LDL-C, HDL-C (men) and triglycerides as compared to normotensive population. KEYWORDS:Non-obese, Non-diabetic, Hypertensive, Dyslipidemia.

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