Mashal Khan, Kanwal Altaf Malik, Uzma Hayat.
ABO incompatibility in neonates coming to a pediatric tertiary care hospital.
Pak J Med Res Jan ;55(4):109-12.

Background: ABO hemolytic disease is the most frequent cause of neonatal jaundice. Objectives: To determine the frequency of ABO incompatibility causing jaundice in neonates coming to a pediatric public sector hospital. Study design, settings and duration: Cross-sectional study conducted at National Institute of Child Health (NICH), Karachi, from 2nd August 2013 to 1st August 2014. Patients and Methods: All neonates of both gender, having serum indirect bilirubin >13 mg/dl and born to mothers having O positive blood group who came to the hospital during the study period were enrolled. Detailed history and physical examination was done in all. Mean± SD were calculated for qualitative variables and categorical variable as frequency and percentages. Chi square test and p-value < 0.05 was taken as significant. Data was analysed in SPSS version 19. Results: A total of 170 neonates were included comprising of 96 male and 74 females. Their mean age was 9.56 ± 2.69 days, mean time of onset of jaundice was 2.86 ± 0.78 days and mean indirect serum bilirubin level was 14.86 ± 1.59 mg/dl. Though all mothers were O positive but the blood group of neonates varied. Majority (72.3%) had blood group O+ followed by B+ (38.2%), A+ (34.0%) and AB+ (27.6%). Among mothers with O+ blood group, the ABO incompatibility was observed in 47 (23.5%) neonates. There was no significant association of ABO incompatibility with gender, age, onset of jaundice and indirect serum bilirubin level (p > 0.05). Conclusion: ABO incompatibility as a common cause of jaundice was seen in 23% neonates. Key words: ABO incompatibility, neonatal jaundice, blood group.

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